A . Recchia Roberto Testa , Luca Menichetti , Antonio L ' Abbate , William C . Stanley
نویسندگان
چکیده
293:H3270-H3278, 2007. First published 5 October 2007; Am J Physiol Heart Circ Physiol A. Recchia Roberto Testa, Luca Menichetti, Antonio L'Abbate, William C. Stanley and Fabio Ciardetti, Cecilia Vecoli, Amalia Gastaldelli, Demetrio Ciociaro, Paola Pellegrini, Danilo Neglia, Alberto De Caterina, Paolo Marraccini, Andrea Natali, Marco idiopathic dilated cardiomyopathy selection flexibility during stress in patients with Impaired myocardial metabolic reserve and substrate
منابع مشابه
TRANSLATIONAL PHYSIOLOGY Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
Danilo Neglia, Alberto De Caterina, Paolo Marraccini, Andrea Natali, Marco Ciardetti, Cecilia Vecoli, Amalia Gastaldelli, Demetrio Ciociaro, Paola Pellegrini, Roberto Testa, Luca Menichetti, Antonio L’Abbate, William C. Stanley, and Fabio A. Recchia Institute of Clinical Physiology, National Council for Research; Department of Medicine, University of Pisa; Scuola Superiore Sant’Anna, Pisa, Ital...
متن کاملImpaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
Under resting conditions, the failing heart shifts fuel use toward greater glucose and lower free fatty acid (FFA) oxidation. We hypothesized that chronic metabolic abnormalities in patients with dilated cardiomyopathy (DCM) are associated with the absence of the normal increase in myocardial glucose uptake and maintenance of cardiac mechanical efficiency in response to pacing stress. In 10 DCM...
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In this study we set up and optimized a dynamic nuclear polarization (DNP) procedure for the hyperpolarization of a large dose suitable for cardiac metabolic imaging in vivo in swine models. The dose range proposed in this study allowed chemical shift imaging of cardiac metabolism with hyperpolarized [1-C]pyruvate in pigs. We investigated the typical pattern of distribution of [1-C]pyruvate and...
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F. Frijia, L. Menichetti, V. Positano, V. Lionetti, C. Forte, J. H. Ardenkjaer-Larsen, M. Milanesi, G. Giovannetti, D. De Marchi, G. Aquaro, M. Campan, F. A. Recchia, L. Landini, M. F. Santarelli, and M. Lombardi MRI Lab, "G. Monasterio" Foundation and Institute of Clinical Physiology, Pisa, Italy, Sector of Medicine, Scuola Superiore Sant'Anna, Pisa, Italy, Istituto per i Processi Chimico Fisi...
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Background 13C Dynamic Nuclear Polarization (DNP) with rapid dissolution together with Magnetic Resonance Chemical Shift Imaging (CSI) have been used for non-invasive real-time metabolic assessment in cardiac experimental models on a clinical 3T scanner. Here, we report an in vivo comparison of hyperpolarized [1-13C] pyruvate and [1-13C] acetate perfusion and metabolism: a method based on a 3D ...
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